Vascular & Interventional Specialists

Leg Cramps at Night? It Could Be a Sign of Peripheral Artery Disease

Jan 05, 2026
Leg Cramps at Night? It Could Be a Sign of Peripheral Artery Disease

Waking up with leg cramps at night is painful, but did you know it may also be a warning sign of an underlying circulatory issue? Peripheral artery disease (PAD) is common, and early evaluation can make a big difference in your health.

Leg cramps in the middle of the night can strike suddenly, jolting you awake with sharp pain in your calves, thighs, or feet. But what causes them? Could they be a sign of an underlying condition?

It’s easy to assume that leg cramps are the result of dehydration, muscle fatigue, or being on your feet all day. 

Those factors can certainly contribute to painful leg cramps, but persistent or recurring night cramps could also indicate a more serious condition called peripheral artery disease (PAD).

PAD happens when the arteries that supply blood to your limbs become narrowed or blocked. When the muscles in your legs don’t get enough oxygen, leg cramps and other symptoms can develop.

Our experienced team at Vascular & Interventional Specialists is here to help. We diagnose and manage PAD in Miami, Florida, and here’s what you should know about leg cramps and other common signs of PAD.

The basics of peripheral artery disease (PAD)

When you have PAD, plaque (fatty deposits) builds up inside the walls of your arteries in a process called atherosclerosis. The buildup slows or blocks blood flow from your heart to other parts of your body, including your legs.

Atherosclerosis can limit the amount of oxygen and nutrients your muscles get, both during activity and while at rest. This reduced circulation can cause a variety of symptoms, which can worsen at night when blood flow slows even further.

PAD develops gradually, so symptoms can be subtle at first. Some of the most common signs include:

1. Leg cramps during activity or at night

Painful cramping in your calves, thighs, or buttocks may occur when walking, climbing stairs, or at night when resting. This pain often improves quickly with light stretching and rest, but episodes may get more frequent or intense over time.

2. Leg numbness or weakness

Reduced circulation can make your legs feel weak, heavy, or numb, especially after exertion.

3. Coldness or changes in skin temperature

Atherosclerosis can make your legs or feet feel cooler than the rest of your body due to poor circulation.

4. Poor healing or sores on legs or feet

Cuts, scrapes, or wounds on your legs and feet may heal slowly or not at all because of limited blood flow.

5. Color changes or shiny skin

Skin on your legs may appear pale, bluish, or shiny, and hair loss on your lower legs can also be a sign of diminished circulation.

Although leg cramps at night can be caused by many factors, when they occur regularly and are accompanied by one or more of the signs above, it’s worth considering PAD as a possible cause.

What to do if you think you might have PAD

If you experience recurring leg cramps at night along with pain during walking, changes in skin color, slow-healing sores, or cold feet, it’s time to get evaluated for PAD. 

PAD is a systemic vascular condition, which means that arteries may also be narrowed elsewhere in your body, including around your heart and brain.

PAD is linked with other cardiovascular diseases, including an increased risk of heart attack and stroke. Identifying it early on helps you avoid progression and better protect your long-term heart and vascular health.

Our team starts by assessing your symptoms, reviewing your medical history, and performing non-invasive tests to evaluate blood flow in your legs. 

If we diagnose PAD, your treatment plan may include a combination of lifestyle changes, medications, or minimally invasive procedures to improve blood flow.

Leg cramps at night may seem harmless, but when they occur regularly or are paired with other symptoms, they could be a sign of PAD. Early detection and intervention can help you manage symptoms, protect your heart, and improve your overall quality of life. 

So, if leg cramps are affecting your sleep or mobility, don’t wait to get answers.

Schedule a consultation with our vascular specialists at 305-230-4664 or book online today.